Folinic Acid 100mg/10ml
With methotrexate: As a rule: 10-15 mg/m2 every 6 hours for approximately 8 to 10 doses, starting 24 hours after the start of methotrexate infusion begins on day 3, based on the residual methotrexate level, if it is > 0.5 µmol/l, calcium folinate dosages should be adapted.
Calcium folinate 200 mg/m2 by intravenous infusion over two hours, followed by bolus 400 mg/m2 of 5-FU (600 mg/m2)
Done for 2consecutive days, every 2 weeks on days 1 and 2
Rescue normal cells from toxic effect of methotrexate.
Modulate the cytotoxic activity of 5-fluorouracil