Composition
Composition:
Folinic Acid 100mg/10ml
Dose
Dose:
With methotrexate: As a rule: 10-15 mg/m2 every 6 hours for approximately 8 to 10 doses, starting 24 hours after the start of methotrexate infusion
begins on day 3, based on the residual methotrexate level, if it is > 0.5 µmol/l, calcium folinate dosages should be adapted.
With 5-flurouracil:
Calcium folinate 200 mg/m2 by intravenous infusion over two hours,
followed by bolus 400 mg/m2 of 5-FU (600 mg/m2)
Done for 2consecutive days, every 2 weeks on days 1 and 2
Indication
Indications:
Rescue normal cells from toxic effect of methotrexate.
Modulate the cytotoxic activity of 5-fluorouracil
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