Cardiovascular

Rotagrreste

Tirofiban is a reversible, competitive inhibitor of GP IIb/IIIa receptors, exerting its effects via the prevention of the binding of activated platelets and fibrinogen, resulting in the inhibition of the last common step of thrombi formation.

 

Indication:

Tirofiban is used to prevent blood clots or heart attack in:

  • NSTEMI/UA patients for medical stabilization either medically managed or undergoing PCI
  • STEMI and NSTEMI patients during PCI for bailout situation or thrombotic complications

 

Dose:

  • Dosage for Medical stabilization of NSTEMI/UA patients either undergoing PCI or Medically managed:

Rotagrreste 0.4 μg per kilogram per minute for 30 minutes, followed by an infusion of 0.1 μg per kilogram per minute

  • For Bailout situation of Thrombotic complications:

Bolus 25 μg/kg over 3 minutes, followed by infusion 0.15 μg/kg/min for 18 Hours